There are primarily two theories as to how hGH (human growth hormone) exerts its growth promoting effects. The first theory is called the Dual Effector theory. The second theory is called the Somatomedin (“mediator of growth”) Hypothesis. Both theories are fairly strait forward. Let?s start with the Dual Effector theory.

Best dosage for hgh is 4-6iu a day!

The Dual Effector theory states that GH itself has anabolic effects directly on body tissues. This theory has been supported by studies looking at the effects of injecting GH directly into growth plates. Genetically altered strains of mice have also help to support this theory. When comparing mice that genetically over express GH and mice that over express insulin-like growth factor-1 (IGF-1), GH mice are larger. Those who support the dual effector theory site this evidence. Interestingly, when IGF-1 antiserum (it destroys IGF-1) is administered concomitantly with GH, all of the anabolic effects of GH are abolished. Clearly IGF-1 has got to be involved somewhere between the pituitary and the target tissue (i.e. muscle). The Somatomedin hypothesis clears things up somewhat.

The Somatomedin hypothesis states that GH exerts its growth promoting effects through IGF-1. More specifically, GH is first released from the pituitary and then travels to the liver and other peripheral tissues where it causes the synthesis and release of IGFs. IGFs work as endocrine growth factors, meaning that they travel in the blood to the target tissues after being released from cells that produced it, specifically the liver in this case. Many studies have been performed showing that animals that are GH deficient, systemic IGF-1 infusions lead to normal growth. Admittedly, the effects are similar to those observed after GH administration. In fact, additional studies have shown IGF-1 to be greatly inferior as an endocrine growth factor requiring almost 50 times the amount to exert that same effects of GH. Recently rhIGF-1 has become widely more available and is currently approved form the treatment of HIV associated wasting. This increased availability allowed testing of this hypothesis in humans. Studies in human subjects with GH insensitivity (Laron syndrome) have consistently validated the somatomedin hypothesis (Rank, 1995; Savage, 1993). These results indicate that although IGF-1 might be the mediator of GH effects, it’s not as simple as just getting the liver to release IGF-1.

So the main difference between these two theories is that the Dual effector theory states that GH doesn?t necessarily need IGF-1 to work, the Somatomedin hypothesis insists it does. In reality both theories are correct. It?s just that the Somatomedin hypothesis focuses on “circulating” IGF-1, the Dual Effector theory recognizes that although IGF-1 is still the active hormone, it doesn’t have to come from the blood (liver), it can be produced on location by the very cells that use it.

In summary, by combining the Dual Effector theory and the Somatomedin hypothesis there are three main mechanisms by which GH makes things grow. First, the effects of GH on bone formation and organ growth are mediated by the endocrine action of IGF-1. As stated in the Somatomedin hypothesis, GH, released from the pituitary, causes increased production and release of IGF-1 into the general circulation. IGF-1 then travels to target tissues such as bones, organs, and muscle to cause anabolic effects.

Second, GH regulates the activity of IGF-1 by increasing the production of binding proteins (specifically IGFBP-3 and another important protein called the acid-labile subunit) that increase the half-life of IGF-1 from minutes to hours. Circulating proteases then act to break up the binding protein/hormone complex thereby releasing the IGF-1 in a controlled fashion over time. GH may even cause target tissues to produce IGFBP-3 increasing its effectiveness locally.

Third, GH may influence the activity of IGF-1 on an autocrine/paracrine level. Autocrine means that a hormone has an effect on the cell that produced it, paracrine means to have an effect on the “cell(s)” next to it as well. This is a completely localized effect, not dependent on the blood stream to carry things where you want them. Muscle growth from weight training is the result of IGF-1 being produced by the muscle cells themselves, not the liver. In fact, IGF-1 form the liver is genetically different from IGF-1 produced in your muscles. This information should explain why using IGF-1 systemically (from the blood stream) has been a hit and miss proposition.

In order to sufficiently address the role of GH and IGF-1 in muscle growth, we need to explore the mechanism of not only IGF-1?s autocrine/paracrine actions, but also the mechanisms of muscle growth itself.

The ability of muscle tissue to constantly regenerate in response to activity makes it unique. Its ability to respond to physical/mechanical stimuli depends greatly on what are called satellite cells. Satellite cells are muscle precursor cells. You might think of them as “pro-muscle” cells. They are cells that reside on and around muscle cells. These cells sit dormant until called upon by growth factors such as IGF-1. Under the influence of IGF-1 these cells divide (proliferate) and genetically change (differentiation) into cells that have nuclei identical to those of muscle cells. These new satellite cells with muscle nuclei are critical if not mandatory to muscle growth.

Without the ability to increase the number of nuclei, a muscle cell will not grow larger and its ability to repair itself is limited. The explanation for this is quite simple. The nucleus of the cell is where all of the blue prints for new muscle proteins come from. The larger the muscle, the more nuclei you need to maintain protein synthesis. There is a “nuclear to volume” ratio that cannot be overridden. Whenever a muscle grows in response to mechanical overload (i.e. weight training) there is a positive correlation between the increase in the number of myonuclei and the increase in muscle cell’s cross sectional area (CSA). When satellite cells are prohibited from donating new nuclei, overloaded muscle will not grow. So you see, one important key to exercise induced muscle growth is the activation of satellite cells by growth factors such as IGF-1.

Few people realize that you can inject a muscle with IGF-1 and it will grow! Studies have shown that, when injected locally, IGF-1 increases satellite cell activity, muscle DNA content, muscle protein content, muscle weight and muscle cross sectional area. I’m not really sure why someone would choose to inject oil instead of IGF-1. Oil gives you lumps and causes your peers to make jokes about you behind your back. IGF-1 just makes the muscle grow and leaves people wondering how you brought up those lagging rear delts.

Scientists are now figuring out the signaling pathway by which mechanical stimulation and IGF-1 activity leads to all of the above changes in satellite cells, muscle DNA content, muscle protein content, muscle weight and muscle cross sectional area just outlined above. This research is stemming from studies done to explain cardiac hypertrophy. It involves a muscle enzyme called calcineurin which is a phosphatase enzyme activated by high intracellular calcium ion concentrations (Dunn, 1999). Note that overloaded muscle is characterized by chronically elevated intracellular calcium ion concentrations. Other recent research has demonstrated that IGF-1 increases intracellular calcium ion concentrations leading to the activation of the calcineurin signaling pathway, and subsequent muscle fiber hypertrophy. I am by no means a geneticist so I hesitated even bringing this research up. To avoid confusion I will enlist the help of the people doing the research. The researchers involved in these studies have explained it this way, IGF-1 as well as activated calcineurin, induces expression of the transcription factor GATA-2, which accumulates in a subset of myocyte nuclei, where it associates with calcineurin and a specific dephosphorylated isoform of the transcription factor nuclear factor of activated T cells or NF-ATc1. Thus, IGF-1 induces calcineurin-mediated signaling and activation of GATA-2, a marker of skeletal muscle hypertrophy, which cooperates with selected NF-ATc isoforms to activate gene expression programs leading to increased contractile protein synthesis and muscle hypertrophy. Simple huh?

Anybody really interested in how muscles grow is going to have to brush up on their genetics (including myself). Until then please don’t send me a barrage of questions about GATA-2 or NF-Atc isoforms. These aren’t things we know how to directly manipulate with supplements yet.

Buy Steroids Part 1 – Understanding Anabolic Steroids

Buy Steroids Generally most beginners will buy steroids in oral form thinking they are safer to use when in fact if you buy steroids to inject they are generally the safest option. Most people will associate needles and syringes with hardcore drugs such as heroine and the thought of sticking a needle in their body will make any beginner nervous. Many oral steroids are liver toxic and unfortunately many beginners do not educate themselves before using them.

Buy Steroids Part 2 – Packing on the Beef..

The base of any bulking cycle is testosterone. There are several types of testosterone that can be used, there are long acting testosterone’s that only need injecting once per week, if you are want fewer injections make sure you buy steroids such as testosterone enanthate, testosterone cypionate and test decanoate. These long acting esters of testosterone can build up pretty heavy in your body and produce dramatic gains, but they do come with their side effects such as gyno, water retention and possibly acne. If this happens be sure to buy steroids along with anti-estrogen and post cycle products.

You can also buy steroids such as testosterone propionate or test suspension, these are fast acting testosterone’s but less dramatic in their effects and side effects. They are in and out your system in 2-3 days meaning more frequent injections however some prefer these types especially when trying to maintain a leaner physique.
Watch out for bad sales pitches online which convince beginners to buy steroids in bulk by putting the idea in your head that more is better when a lot of the time this is absolute rubbish. This sort of information will say that you will need 500mg’s per week when in fact the standard dose for any beginner is 250-300mg’s per week.

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Buy Steroids Part 3 – Getting Ripped..

Getting ripped can be hard on the body but its worth the hard work. Assuming your diet is in check and you are doing cardio and weight training and getting decent rest then you should buy steroids designed for cutting cycles.

A very popular cutting steroid to buy is Trenbolone, this is popular purely because this is considered a condition freaks dream this stuff. It can be hard on the kidneys so plenty of water needs to be consumed but hey if you want to buy steroids to get that ripped look consider Trenbolone Acetate or Trenbolone Enanthate.
A great cutting steroid to buy is Anavar, this produces slow steady quality gains and also produces a great strength increase which is much needed when dieting hard and also doing cardio work as well as weight training.

You can also buy steroids like Masteron, this is a personal favourite of forbodybuilders as this has a brilliant hardening effect on the body which is key for that solid ripped look.

Many people also buy steroids to use in conjenction with each other such as Primobolan Depot and Winstrol which will give slow, steady lean and hard gains which you will keep most of your gains when you come off them.

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Buy Steroids Part 4 – Other Steroids….
A very popular selling steroid is Deca which is normally used in conjuction with testosterone on bulking stack. Many users buy steroids like Deca Durabolin for its increase in nitrogen in the blood and also has the benefits of lubricating sore joints from heavy lifting.

Equipoise , boldabolic is a popular veterinary steroid which is safe for human consumption, this can be used for adding mass, or while dieting. Equipoise will give a slow, steady increase in mass and strength. Another plus to equipoise is that it increase appetite, which makes it more appropriate for bulking than cutting. 150mgs every three days will yield impressive results. Equipoise is a rather safe steroids, with no major side effects. It has been my many users at 800-1000mgs a week without any noticeable side effects.

Buy Steroids Part 5 – Keeping The Beef After Your Cycle…

Many people only buy steroids , but when coming off a steroid cycle you need to use anti-estrogen / post cycle therapy products which will ensure you keep most of your gains. Nolvadex can be used to fight estrogen and slightly raise testosterone levels when they drop when you come off the steroids, many buy clomid as it can normalize the testosterone level and the spermatogenesis (sperm development) within 10-14 days. For this reason Clomid is primarily taken after steroids are discontinued. At this time it is extremely important to bring the testosterone production to a normal level as quickly as possible so that the loss of strength and muscle mass is minimized. So make sure when you’re buying steroids, you also get post cycle products ready for the end of your cycle.

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These are FDA approved for the treatment of undescended testicles in young boys, hypogonadism (underproduction of testosterone) and as a fertility drug used to aid in inducing ovulation in women. When prepared as a medical item, this hormone comes from a human origin. Although there is often a fear of biological origin products, there is little research to be found regarding pathogen or sterility problems with HCG. The problems seen with human origin growth hormone are certainly not to be repeated with HCG, as this compound is obtained in a much different way.

While HCG offers the female no performance enhancing ability, it does prove very useful to the male steroid user. The obvious use of course being to stimulate the production of endogenous testosterone. The activity of HCG in the male body is due to its ability to mimic LH (luteinizing hormone), a pituitary hormone that stimulates the Leydig?s cells in the testes to manufacture testosterone. Restoring endogenous testosterone production is a special concern at the end of each steroid cycle, a time when a subnormal androgen level (due to steroid induced suppression) could be very costly. The main concern is the action of cortisol, which in many ways is balanced out by the effect of androgens. Cortisol sends the opposite message to the muscles than testosterone, or to breakdown protein in the cell. Left unchecked (by an extremely low testosterone level) in the body, cortisol can quickly strip much of your new muscle mass away.

The main focus with HCG is to restore the normal ability of the testes to respond to endogenous luteinizing hormone. After a long period of inactivity, this ability may have been seriously reduced. In such a state testosterone levels may not reach a normal point, even though the release of endogenous LH has been resumed. Many who have suffered severe testicular shrinkage may be able to relate, as it is often some time before normal testicle size and feelings of virility are restored if ancillary drugs had not been used. The excessive stimulation brought forth by administration of HCG can likewise cause the testicles to rapidly return to their normal size and level of activity. We are not simply looking for it to fix the problem however, as the resulting high testosterone level can itself trigger negative feedback inhibition at the hypothalamus. Estrogen production is also heightened with the use of HCG, due to its ability to increase aromatase activity in the Leydig?s cells. This is due to the main action of HCG, namely the increase of cycIicAMP (a secondary messenger that regulates cellular activity). When stimulated by HCG, the ability of the testes to aromatize androgens could potentially be heightened several times greater than normal. This also may inhibit testosterone production, so we therefore use HCG only as a quick shock to the testes.

The usual protocol is to inject 1500-3000 I.U. every 4th or 5th day, for a duration usually no longer than 2 or 3 weeks. If used for too long or at too high a dose, the drug may actually function to desensitize the Leydig?s cells to luteinizing hormone, further hindering a return to homeostasis. Timing the initial dose is also very crucial. If your were coming off a cycle of Sustanon for example, testosterone levels in your blood will likely stay elevated for at least 3 to 4 weeks after your last injection. Taking HCG on the day of your last shot would therefore be useless. Instead one would want to calculate the last week in which androgen levels are likely to be above normal, and begin ancillary drug therapy at this point. In this case HCG would be started around the third or fourth week. Likewise, after ending a cycle of Dianabol (an oral) your blood levels will be sub normal after the third day. Here you may want to begin HCG therapy a few days before your last intake of tablets, giving it a few days to take effect. One would also want to give some thought to the level of suppression that the cycle might have brought about. After an 8 week cycle of Equipoise for example, 1500-2500 I.U. would likely be a sufficient initial dosage. The lower amount of hormonal suppression one associates with this drug would probably not require much more. On the other hand, 750-1000mg of Sustanon per week might incline the user to inject a much larger HCG dose, perhaps as much as 5000 I.U. for the opening application. It may thereafter also be a good idea to reduce the dosage on subsequent shots, so as to step down the intake of HCG during the two or three weeks of intake.

As discussed above, HCG acts only to mimic the action of LH. It is likewise not the perfect hormone to combat testosterone suppression, and for this reason it is used most often in conjunction with estrogen antagonists such as Clomid, Nolvadex or cyclofenil. These drugs have a different effect on the regulating system, namely inhibiting estrogen-induced suppression at the hypothalamus. This of course also helps to restore the release of testosterone, although through a much different mechanism than HCG. A combination of both drugs appears to be very synergistic, HCG providing an immediate effect on the testes (shocking them out of inactivity) while the anti-estrogen helps later to block inhibition on the hypothalamus and resume the normal release of gonadotropins from the pituitary. The typical procedure involves giving the Clomid/Nolvadex dose from the start with HCG, but continuing it alone for a few weeks once HCG has been discontinued. This practice should effectively raise testosterone levels, which will hopefully remain stable once Clomid/Nolvadex have been discontinued. While unfortunately there is no way to retain all of the muscle gains produced by anabolic steroids, using ancillaries to restore a balanced hormonal state is the best way to minimize the loss felt with ending a cycle.

Deca-Durabolin is the most widespread and most commonly used injectable steroid. Its popularity is due to the simple fact that it exhibits many very favorable properties. Structurally nandrolone is very similar to testosterone, although it lacks a carbon atom at the 19t? position (hence its other name 19-nortestosterone). The resulting structure is a steroid that exhibits much weaker androgenic properties than testosterone. Of primary interest is the fact that nandrolone will not break down to a more potent metabolite in androgen target tissuess?. You may remember this is a significant problem with testosterone. Although nandrolone does undergo reduction via the same (5-alpha reductase) enzyme that produces DHT from testosterone, the result in this case is dihydronandrolone.

HOW TO USE DECA-DURABOLIN by TerePharmacy.com : Deca-Durabolin causes the muscle cell to store more nitrogen than it releases so that a positive nitrogen balance is achieved. A positive nitrogen balance is synonymous with muscle growth since the muscle cell, in this phase, assimilates (accumulates) a larger amount of protein than usual. The same manufacturer, however, points out on the package insert that a positive nitrogen balance and the protein building effect that accompany it will occur only if enough calories and proteins are supplied. The highly anabolic effect of Deca-Durabolin is linked to a moderately androgenic component, so that a good gain in muscle mass and strength is obtained. At the same time, most athletes notice considerable water retention which, no doubt, is not as distinct as that with injectable testosterones but which in high doses can also cause a smooth and watery appearance. Since Deca-Durabolin also stores more water in the connective tissues, it can temporarily case or even cure existing pain in joints. This is especially good for those athletes who complain about pain in the shoulder, elbow, and knee; they can often enjoy pain-free workouts during treatment with Deca-Durabolin. Athletes use Deca-Durabolin, depending on their needs, for muscle buildup and in preparation for a competition.

DECA-DURABOLIN DOSAGE : Deca-Durabolin is suitable, even above average, to develop muscle mass since it promotes the protein synthesis and simultaneously leads to water retention. The optimal dose for this purpose lies between 200 and 600mg/week.Scientific research has shown that best results can be obtained by the intake of 2 mg/pound body weight. Those who take a dose of less than 200 mg/week will usually feel only a very light anabolic effect which, however, increases with a higher dosage. Steroid novices usually need only 200 mg/week. Deca-Durabolin works very well for muscle buildup when combined with Dianabol and Testosterone. The famous Dianabol/Deca-Durabolin stack results in a fast and strong gain in muscle mass. Most athletes usually take 15-40 mg Dianabol/day and 200-400 mg Deca-Durabolin/week. Even faster results can be achieved with 400 mg Deca-Durabolin/week and 500 mg Sustanon/week.

Side Effects with Deca-Durabolin: side effects with Deca-Durabolin are relatively low with dosages of 400 mg/week, androgenic caused side effects can occur. Most problems manifest themselves in high blood pressure and a prolonged time for blood clotting, which can cause frequent nasal bleeding and prolonged bleeding of cuts, as well as increased production of the sebaceous gland and occasional acne. Some athletes also report headaches and sexual overstimulation. When very high dosages are taken over a prolonged period, spermatogenesis can be inhibited in men, i.e. the testes produce less testosterone. The reason is that Deca-Durabolin, like almost all steroids, inhibits the release of gonadotropins from the hypophysis.

Women with a dosage of up to 100 mg/week usually experience no major problems with Deca-Durabolin. At higher dosages androgenic caused virilization symptoms can occur, including deep voice (irreversible), increased growth of body hair, acne, increased libido, and possibly clitorihypertrophy. Women who experience disturbance even at a weekly dose of only 50 mg/week of Deca-Durabolin, are often better off taking the earlier mentioned and faster acting Durabolin. Deca-Durabolin, through its increased protein synthesis, also leads to a net muscle gain and Oxandrolone, based on the increased phosphocreatine synthesis, leads to a measurable strength gain with very low water retention. Other variations of administration used by female athletes are Deca-Durabolin and Winstrol tablets, as well as Deca-Durabolin and Primobolan.

On the black market Deca remains one of the most popular anabolics in circulation. Currently 200mg/ml preparations from Mexico are dominating the marketplace, and due to their high availability and lower cost are minimizing the appearance of lower dosed compounds. For example, in addition to Norandren 200 Brovel also makes Norandren 50 (a 50 mg/ml version of this steroid), but it is almost unseen right now. I should point out that their 50m1 vial of Norandren 200 is also the largest container of nandrolone to be found in such strength, and represents one of the best values anywhere for this steroid. We can see why it is much more desired right now. Also common are Nandrolona 200 from Tornel and Decanandrolen from Denkall, both in 1 Oml vials. In an effort to provide more innovative, conspicuous and cost-effective products, the Mexican firm Ttokkyo has recently topped its competitors and released Nandrolona 300. This is a 300mg/ml preparation of nandrolone decanoate, which is by far the highest dose of this compound ever to be produced commercially. To spite the defiant opinions of many, indeed this is a legitimate product. I have not experimented with the solubility of nandrolone decanoate myself, but do know that this particular ester is highly fat-soluble. Reaching 300mg in a milliliter of oil does not seem like an unreasonable or impossible task, and I would guess requires at best some minor tweaking of alcohol levels (perhaps none at all).

Anadrol is the strongest and also the most effective oral steroid. Anadrol has an extremely high androgenic effect which goes hand in hand with an extremely intense anabolic component. Anadrol is the U.S. brand name for oxymetholone, a very potent oral androgen. This compound was first made available in 1960, by the international drug firm Syntex. Since oxymetholone is quite reliable in its ability to increase red blood cell production (and effect admittedly characteristic of nearly all anabolic/androgenic steroids), it showed particular promise in treating cases of severe anemia. For this reason, dramatic gains in strength and muscle mass can be achieved in a very short time. An increase in body weight of 10 – 15 pounds or more in only 14 days is not unusual. This item is shown to have a much more direct effect on the red blood cell count, without the side effects of a strong androgen.
Anadrol is considered by many to be the most powerful steroid available, with results of this compound being extremely dramatic. A steroid novice experimenting with oxymetholone is likely to gain 20 to 30 pounds of massive bulk, and it can often be accomplished in less than 6 weeks, with only one or two tablets per day. This steroid produces a lot of trouble with water retention, so let there be little doubt that much of this gain is simply bloat. But for the user this is often little consequence, feeling bigger and stronger on Anadrol than any steroid they are likely to cross. This will allow for more elasticity, and will hopefully decrease the chance for injury when lifting heavy. It should be noted however, that on the other hand the very rapid gain in mass might place too much stress on your connective tissues for this to compensate. Pronounced estrogen trouble also puts the user at risk for developing gynecomastia. Individuals sensitive to the effects of estrogen, or looking to retain a more quality look, will therefore often add Nolvadex to each cycle.
Clearly if this is the case we can only combat the estrogenic side effects of oxymetholone with estrogen receptor antagonists such as Nolvadex or Clomid, and not with an aromatase inhibitor. The strong anti-aromatase compounds such as Cytadren andArimidex would similarly prove to be totally useless with this steroid, as aromatase is uninvolved.
Anadrol is also a very potent androgen. This trait tends to produce many pronounced, unwanted androgenic side effects. Oil skin, acne and body/facial hair growth can be seen very quickly with this drug. Many individuals respond with severe acne, often requiring medication to keep it under control. Some of these individuals find that Accutaine works well, which is a strong prescription drug that acts on the sebaceous glands to reduce the release of oils. Those with a predisposition for male pattern baldness may want to stay away from Anadrol 5007 completely, as this is certainly a possible side effect during therapy. And while some very adventurous female athletes do experiment with this compound, it is much too androgenic to recommend. Irreversible virilization symptoms can be the result and may occur very quickly, possibly before you have a chance to take action.

HOW TO USE ANADROL : Anadrol is unfortunately also the most harmful oral steroid. Its intake can cause many considerable side effects. Since it is I 7-alpha alkylated it is very liver toxic. Most users can expect certain pathological changes in their liver values after approximately one week. An increase in liver values of both the enzymes GOT and GPT also called transaminases, often cannot be avoided. Elevated GOT and GPT values are indications of hepatitis, i.e. a liver infection. Longer intake and/or higher doses can cause a yellow discoloration of fingernails, eyes, or skin jaundice). This is because oxymetholone induces an increase of biliburin in the liver, producing a bile pigment which causes the yellow discoloring of the skin. The liver enzyme gamma-GT also reacts sensitively to the oxymetholone, causing it to elevate
Other possible side effects may include headaches, nausea, vomiting, stomach aches, lack of appetite, insomnia, and diarrhea. The athlete can expect a feeling of ?general indisposition? with the intake of Anadrol which is completely in contrast to Dianabol which conveys a ?sense of wellbeing?. The increased aggressiveness is caused by the resulting high level of androgen and occurs mostly when large quantities of testosterone are ?shot? simultaneously with the Anadrol. The body?s own production of testosterone is considerably reduced since Anadrol has an inhibiting effect on the hypothalamus, which in turn completely reduces or stops the release of GnRH (gonadotropin releasing hormone). For this reason the intake of testosterone stimulating compounds such as HCG and Clomid is absolutely necessary to maintain the hormone production in the testes.

ANADROL DOSAGE : As for the dosage, opinions differ. A dosage sufficient for any athlete would be 0,5 – 0,8 mg per pound of body weight/day. This corresponds to 1-4 tablets; i.e. 50-200 mg/day. Under no circumstances should an athlete take more than four tablets in any given day. We are of the opinion that a daily intake of three tablets should not be exceeded. Those of you who would like to try Anadrol for the first time should begin with an intake of only one 50 mg tablet. After a few days or even better, after one week, the daily dosage can be increased to two tablets, one tablet each in the morning and evening, taken with meals. Athletes who are more advanced or weigh more than 220 pounds can increase the dosage to 150 mg/day in the third week.Athletes continue their treatment with injectable testosterone such as Sustanon or Testosterone enanthate for several weeks. Bodybuilders often combine Anadrol with Deca-Durabolin or Testosterone to build up strength and mass. Anadrol is to be taken seriously and the prevailing bodybuilder mentality ?more is better? is out of place.

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Anabolics 2009 – Anabolics 9th Edition by William Llewellyn (BOOK)
Anabolics 2009, officially entitled “William Llewellyn’s Anabolics 9th Edition,” is now available for immediate delivery!
William Llewellyn’s ANABOLICS has been the most trusted anabolic steroid information resource for more than a decade. Considered the definitive reference manual on physique- and performance-enhancing drugs, this book includes an extensive review of the history, availability, clinical application, and practical use of anabolic/androgenic steroids, human growth hormone, insulin, anti-estrogens, diuretics, reductase inhibitors, thyroid hormones, stimulants, and a variety of other performance medications. The latest (9th) edition has been fully updated, and is the most comprehensive and informative version of this legendary book ever published!
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William Llewellyn about Asia Pharma

“AP appears to be a legitimate registered company with a real lab, or at the very least has a real production facility making their products. I would definitely recommend staying away from all underground water-based products. I think most are contaminated.

AP, being a registered company, should be making the product correctly. Can’t say anything for certain, obviously, not having tested such an item.”

One of the most popular places that people recommend to buy anabolic steroids is Thailand. Besides physically going to Thailand, there are also websites which advertise Thai anabolic steroids. So the question is how easy is to get Thai anabolic steroids?
Anabolic Sniffing Dog Website: There are many websites that offer all types of anabolic steroids. The steroids are considerably a lot cheaper than what is advertised by the European or Mexican websites. However, there are many problems with buying online steroids from Thailand. First the authenticity of the steroids can never be verified.
There are many cases where after the order, fake drugs have been shipped. Second, how does one get the drugs back to America? Shipping from Thailand is always viewed with suspicion by the postal authorities. And the majority of shipments like boxes or parcels from Thailand are almost always screened for drugs. Dogs routinely sniff through the packages. Even a pharmacy address immediately adds suspicion. And even if you do not give your own home address, the DEA has a habit of following the packages to the PO Box number you are using (the majority of PO Boxes are under watch for suspicious parcels). And once you have given your Credit Card online, you can surely bet that some one is going to be enjoying a great holiday in Pattaya with some beautiful babes- courtesy of you. In short, ordering any type of drug online from Thailand is fraught with problems- chances are more likely than not that you will be caught. And if you do not get caught in the US, rest assured, the drugs that you will get will most likely be fakes.
Going to Thailand. Many people go to Thailand to enjoy the good life. The place is cheap, people are friendly and one can buy almost anything. The actual rules about anabolic steroids in Thailand appear murky. If you read some of the body building websites, most people think that Thailand has no rules about anabolic steroids. Some people believe that anabolic steroids are legal in Thailand.

The facts first. Anabolic steroids in Thailand are illegal. While a local may get away with possession, you can rest assured that Thai authorities will take you to prison. There is a large DEA personnel attachment that currently works with the Thai authorities and they are just as happy to see you go visit the Thai prisons. Of course, I have never been to a Thai prison, but I have yet to meet someone who had a great time. At least from what I have seen and heard, it is not a night out in Bangkok with pretty girls.
Imprisoned for Illegal Steroids

There are many pharmacies which do sell anabolic steroids in Thailand. The majority of these steroids are for veterinary use but foreigners or Farangs as they are called, look and behave like animals anyway in Thailand- so most pharmacies will sell them to you. And even though prescriptions are required, most Thai pharmacies simply ignore that crap paper. And if the pharmacy really does get picky, you can always go to a Thai doctor who will write a prescription for your animal back home.

You may think that just because you bought the anabolic steroids from a legal pharmacy in Thailand may be the real thing- wrong. There are countless anabolic steroids in Thai pharmacies which are fake. In Thailand, almost anything goes; Rules are non existent except when you are caught in possession of illicit drugs or anabolic steroids.
Equipment for Building Muscle The next trip is always to the gym. Just like America, Thai men want to look great. And they do use anabolic steroids. There are many reports that the real drugs can be easily bought at the gym for a relatively cheap price. There are hundreds of gyms all over Bangkok and getting to know a body builder is essential. Most will point you in the right direction. Recently there have been reports of many foreigners being busted in Thai gyms for possessing anabolic steroids- so make sure the body builder you go to is not an informant, other wise you will be spending more time building your body cleaning Thai BOGS in prison.

Once you have bought the anabolic steroids, is it difficult to bring them to the USA? Well, this depends a lot on luck more than anything else. Sure, you can bring a few pills but if you are caught at the airport with anabolic steroids, at least you will get a chance to meet Jose Canseco in prison.

In the last few years, the DEA has been working with Thai authorities to shut down the trade in anabolic steroids. Every single day, foreigners are caught with these drugs and the punishment is not light. The Thai authorities have also shut down many illegal factories that produce anabolic steroids.

So where do we stand with Thailand and anabolic steroids today? Well, the place has great beaches, good weather and excellent food. Even the girls are submissive and give great massages. As far as anabolic steroids are concerned, one should forget Thailand.

In this land of Siam, there are many good things but buying anabolic steroids and going to prison is definitely not one of them.

Almost weekly someone posts on the Chemical Enhancement forum asking about first cycle advice. The most common questions are; “what steroid should I take?” “How long should I take it?” and “What will the effects be?” There are literally dozens of steroids available and that makes it difficult for a first time user to choose. The following information will attempt to provide enough information for a first time user to make an educated decision about anabolic androgenic steroid use.

Testosterone is one of the most effective, safe and available steroids today, therefore I believe Testosterone is the best first cycle choice. The following text outlines the benefits and risks of Testosterone administration based on a clinical human trial of 61 healthy men in 2001. The purpose of the trial was to determine the dose dependency of testosterone’s effects on fat-free mass and muscle performance. In this trial 61 men, 18-35years old were randomized into 5 groups receiving weekly injections of 25, 50, 125, 300, 600 mg of Testosterone enanthate for 20 weeks. They had previous weight-lifting experience and normal T levels. Their nutritional intake was standardized and they did not undertake any strength training during the trial. The only two groups that reported significant muscle building benefits were the 300 and 600 mg groups so any dose lower than 300mg will not be considered in this essay. 12 men participated in the 300 mg group and 13 men in the 600 mg group.
600mg of Testosterone a week for 20 weeks resulted in the following benefits. Increased fat free mass, muscle strength, muscle power, muscle volume, hemoglobin and igf-1.

The same 600 mg administration resulted in 2 side effects. HDL cholesterol was negatively correlated and 2 men developed acne.

The normal range for total T in men is 241-827 ng/dl according to Labcorp and 260-1000 ng/dl according to Quest Laboratories. The normal range for igf-1 is 81-225 according to Labcorp. Total T and igf-1 levels were taken after 16 weeks and resulted in the following;

Total Testosterone
300 mg group-1,345 ng/dl a 691 ng increase from baseline
600 mg group-2,370 ng/dl a 1,737 ng increase from baseline
igf-1
300 mg group-388 ng/dl a 74 ng increase from baseline
600 mg group-304 ng/dl a 77 ng increase from baseline

Body composition was measured after 20 weeks.

Fat Free Mass by underwater weighing
300 mg group-5.2kg (11.4lbs) increase
600 mg group-7.9kg (17.38lbs) increase
Fat Mass by underwater weighing
300 mg group-.5kg (1.1lbs) decrease
600 mg group-1.1kg (2.42lbs) decrease
Thigh Muscle Volume
300 mg group-84 cubic centimeter increase
600 mg group-126 cubic centimeter increase
Quadriceps Muscle Volume
300 mg group-43 cubic centimeter increase
600 mg group-68 cubic centimeter increase
Leg Press Strength
300 mg group-72.2kg (158.8lbs) increase
600 mg group-76.5kg (168.3lbs) increase
Leg Power
300 mg group-38.6 watt increase
600 mg group-48.1 watt increase
Hemoglobin
300 mg group-6.1 gram per liter increase
600 mg group-14.2 gram per liter increase
Plasma HDL Cholesterol
300 mg group-5.7 mg/dl decrease
600 mg group-8.4 mg/dl decrease
Acne
300 mg group-7 of the 12 men developed acne
600 mg group-2 of the 13 men developed acne

There were no significant changes in PSA or liver enzymes at any dose up to 600mg. However, long-term effects of androgen administration on the prostate, cardiovascular risk, and behavior are unknown. The study demonstrated that there is a dose dependant relationship with testosterone administration. In other words the more testosterone administered the greater the muscle building effects and potential for side effects.

Given the results of the study and based on years of personal experience I believe the first time user can safely use between 300-600 mg of testosterone enanthate or cypionate per week for 8-12 weeks. Because it is desirable to have even blood androgen levels I advise at least 2 equal injections per week. The following graph demonstrates that testosterone cypionate peaks within 1-2 days after injection and falls off to almost baseline by day 10. Therefore waiting 7 days between injections of cypionate would cause wide fluctuations in blood androgen levels.

Pharmacokinetics of Testosterone cypionate Injection

Source: Schulte-Beerbuhl, 1980
Figure. Pharmacokinetics of 200mg Testosterone cypionate injection. Source: Comparison of Testosterone, dihydrotestosterone, luteinizing hormone, and follicle-stimulating hormone in serum after injection of Testosterone enanthate or Testosterone cypionate. Schulte-Beerbuhl M, Nieschlag E. Fertility and Sterility 33 (1980) 201-3.

If a first time user wanted to use 600 mg of cypionate or enanthate per week he would inject 300 mg on Tuesday and another 300 mg on Saturday each week for 10 weeks. When injecting long heavy esters like cypionate with this frequency I tend to have less acne then 1 injection per week.

There are a number of esters which provide varying release times. Acetate or propionate esters extend the release time of testosterone a couple of days. In contrast, a deconate ester prolongs the release of testosterone about 3 weeks. Testosterone enanthate and cypionate are almost identical esters. The use of an ester allows for a less frequent injection schedule than using a water based testosterone like suspension which has no ester at all and is rapidly in and out of your system after injection. The published release times are not exact and are many times based on a single injection not many multiple injections which can delay the release of the hormone. Other factors affect release times of esters such as scar tissue and the muscle group injected. Only a blood test can confirm when the active hormone has cleared your system.

Esters not only effect release times but also the potency of the Testosterone as esters make up part of the steroid weight. This must be taken into account when calculating dosages. The longer the release time the less free hormone. For example propionate is about 15% more potent mg. for mg. then enanthate so 500mg of propionate would equal about 575 mg. of enanthate. The following chart illustrates the free base equivalents for several compounds.

Although it was not indicated in the trial, during or after the steroid cycle some men are prone to gynecomastia which is the formation of female like breast tissue. This is due to excessive estrogen as the body tries to balance out the sex hormones. A selective estrogen receptor modulator or S.E.R.M. such as Tamoxifen can be used effectively to combat gynecamastia in an emergency as it competes for the estrogen receptor which in turn inhibits estrogens effects. It is highly recommended that a S.E.R.M. be available during treatment of Testosterone. 10-40mg daily is an effective dose however dosage is dependant on how much testosterone is administered as well as the individual himself.

The decision to use steroids should not be taken lightly and should be the last consideration after implementing a solid nutritional, training and recovery plan. It is advised to get blood work when using these medications.

Testosterone dose-response relationships in healthy young men

Ancillaries during the cycle

Aromatase Inhibitor

I briefly wrote about using Tamoxifen above for emergency gynecomastia treatment however I am convinced that there is a better strategy for controlling estrogen during a steroid cycle. Rather than waiting for the side effects of estrogen to present an aromatase inhibitor like Arimidex or Aromasin should be used on cycle to control Estrogen and keep free testosterone levels high. 0.5mg-1mg Arimidex daily OR 10-25mg Aromasin daily. Start with the lower dose and then see how that controls water retention, blood pressure and libido and make adjustments as needed. A blood test would be the most ideal way to determine the dosage of the AI. Free T needs to be in the high range and estradiol between 10-25 pg/ml.

Human Chorionic Gonadotropin

Testosterone-Induced gonadotropin suppression tends to cause atrophy of the testes and decreases intratesticular testosterone. In other words, when a male administers testosterone his testes shrink because they are suppressed. A simple way to restore ITT levels and maintain the mass of the testes is to administer HCG during testosterone treatment. During a study it was determined that HCG is dose dependant and that approximately 300iu HCG taken every other day restored ITT levels. This is 1,050iu HCG weekly. I recommend 500iu twice weekly while on testosterone treatment. On a very heavy cycle a third dose of 500iu could be added but that is typically not needed. HCG will not only keep ITT levels and the mass of the testes normal but will also aid in keeping the male fertile.

Sample cycle with ancillaries

Sunday 10mg Aromasin
Monday 10mg Aromasin/500iu HCG
Tuesday 10mg Aromasin/300mg enanthate
Wednesday 10mg Aromasin
Thursday 10mg Aromasin
Friday 10mg Aromasin/500iu HCG
Saturday 10mg Aromasin/300mg enanthate

For all you guys who want to add multiple compounds to your first course I advise against it because if you have side effects then you will not know which compound is causing the sides. I have gotton a ton of PM’s over the years and there is always some reason that I am given for using multiple compounds on the first run but there really is no need. However my cycle sample above may not be for everyone so I am offering an alternative to the flat cycle design. If you want to run a first cycle with a little more horespower than you may want to consider a modified pyramiding cycle. I have done over 20 pyramid courses and must say they are my favorite way to run aas. The human body is always fighting for homeostasis so the concept is to increase dose before gains plateau. Based on the 2009 myostatin study we can design a cycle that is effective for 10 weeks using this strategy. The following first cycle is for men that want a little more performance with added risk while only using Testosterone. The first 5 weeks a standard dose is administered to evaluate how your body responds and to determine if sides are manageable. If sides are manageable then increase the dose.

Sample first course #2

Week 1-5 600mg Testosterone weekly
Week 6-8 800mg Testosterone weekly
Week 9-10 1 gram Testosterone weekly

10 mg Aromasin daily with the goal of keeping Estradiol between 10pg/ml-25pg/ml. Only blood work can confirm if you are in this range.

500iu HCG twice weekly.

Post Cycle therapy

I strongly believe that an AI should be used as long as there is an aromatizing compound being administered. In this case Testosterone and HCG aromatize therefore using an AI until these meds clear and a few weeks longer is what I am recommending. There is some evidence that adding Nolva to an AI does not increase the effectiveness of estro control therefore Nolva has no real advantage alongside an AI unless one is experiencing gyno. Additionally Nolva has been shown to reduce igf-1 and GH levels when used alone. This is not a big deal on cycle as testosterone increases igf-1 in a dose dependant relationship. However off cycle this is a problem. PCT is a fragile time and lower igf-1 and GH levels is not desirable. I am recommending an AI that is specific to men that can be used on cycle and during PCT. It is my conclusion that Aromasin is the obvious choice.

I recommend the following PCT protocol for esters like cypionate and enanthate;

Day 1-16 : 2500iu HCG every other day. (You may use less HCG if your testes are normal in size AND you have been using HCG on cycle, i.e. 1,000iu HCG etd.)

100/100/100/50 clomid (50mg taken twice per day weeks 1-3 after aas ester clears)

20mg/20mg/20mg/10mg Aromasin (20mg daily for 3 weeks, 10mg daily in week 4)

3g Vit C every day split in 3 doses

10g creatine daily

The HCG is administered BEFORE the ester clears to increase the mass of the testes and bring back ITT levels. This will allow the testes to sustain output of testosterone sooner.

clomid is universally accepted as THE testosterone recovery tool. It blocks estrogen from the HPTA and stimulates the production of GNRH then initiates the production of LH, which in turn signals the testis (if not atrophied) to produce testosterone.

Aromasin or a similar aromatase inhibitor is for testosterone recovery and it is used to keep the testosterone/estrogen balance in favor of testosterone. It is also helps to keep any additionally occurring estrogen from HCG low to none.

Cortisol is catabolic. It is the enemy of all anabolism and must be kept in check. While it is blocked when under the influence of AAS, it is free to attach to the Anabolic Receptors (AR) once the steroids leave. Due to this blockage Cortisol tends to accumulate and increase when on. A low level is desirable however since it is important for other vital functions such as control of inflammation. Balance is the key. Vitimin C keeps the exercise induced rise of Cortisol in check.

The use of Creatine has shown to increase ATP metabolism and cellular water storage among many other things. This is beneficial because it provides for heightened nutrient storage and a slight increase in anabolism as well as workout stamina.

References

Testosterone dose-response relationships in healthy young men;

Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males

Low-Dose Human Chorionic Gonadotropin Maintains Intratesticular Testosterone in Normal Men with Testosterone-Induced Gonadotropin Suppression

Use of clomiphene citrate to reverse premature andropause secondary to steroid abuse.

special thanks to those men and women who have influnced my thinking over the years in regards to aas use.

~heavyiron