The chemical structure of Trenbolone Enanthate is 17β-Hydroxyestra-4, 9, 11-trien-3-one.Its other names and terms are Tren, Tren Acne, Tren E, Hexahydrobenzylcarbonate Cyclohexylmethylcarbonate, and Fina. Trenbolone Enanthate is produced by underground labs to replace Parabolan and its obscure ester. This is an oil based steroid and is basically used for veterinary purposes and for bodybuilding & powerlifting. Trenbolone Enanthate is exclusively used to build up strength and mass. It is a viable compound for those who want to make minimal injections and at the same time use a nice lean-mass providing, non-aromatizing anabolic.

Warnings And Precautions

Trenbolone Enanthate is a steroid which possesses strong androgenic properties. Sweating and a decrease in cardiovascular capability are often widely reported with Trenbolone Enanthate usage. Trenbolone Enanthate is not suitable for one who plays any kind of sports that require cardiovascular fitness. Sweating has been reported greatly at night time, with insomnia and even strange dreams might take place. It is recommended that water intake should be efficient while consuming Trenbolone Enanthate because it tend to causes loss of water.

However, it is said that Trenbolone Enanthate does not aromatise, but since the estrogen manifests progesterone related side effects, such as gynecomastia, it should be seriously kept in mind while stacking it with other androgenic anabolic steroids, such as testosterone. Trenbolone Enanthate is also reported to be very harsh on the HTPA function. Moreover, its recovery is also said to be harsher than steroids and because of this, the use of HCG is often advised.

Uses

Trenbolone Enanthate (Tren) users widely experience side effect though they can expect rapid gains in muscle size and strength. The steroid is often used in cutting cycles due to its ability to cause hardening of the muscles, and positively changing a person’s body composition. Trenbolone Enanthate is also said to be responsible for some level of fat loss, but we should not rely on the compound for this benefit. Due to its high androgenic characteristics, Trenbolone Enanthate is not really a suitable steroid to be taken by women. It is generally used by athletes and bodyguards. It can also improve feed efficiency and mineral absorption in animals. A sports person is advised to take Trenbolone Enanthate in the beginning of the sports season and gradually stack it with other anabolic steroids.

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Mechanism

Trenbolone Enanthate tends to bond to the Androgen Receptor very strongly and this is the cause of its fat-burning ability and muscle building abilities. Trenbolone Enanthate usage produces new muscle fibers in a considerable amount.This can be done partly by increasing IGF-1 within the muscle tissues and then by increasing the total amount of DNA per muscle cell.along with an increase in the sensitivity of the muscle satellite to IGF-1 and some other growth factors).Trenbolone Enanthate also increases both protein synthesis as well as nitrogen retention in muscle tissue and can bind with the (anti-anabolic) glucocorticoid receptor (6-7), hence it aids the muscle building process.

Side Effects

Trenbolone Enanthate strongly impacts on the endogenous testosterone and because of this, use of a stimulating drug like Clomid/Nolvadex and HCG is highly advised while ending a steroid therapy. Other wise, there might be a hormonal imbalance, for example testes may not be able to respond normally to the resumed output of endogenous gonadotropins due to an atrophied state.

Some of the other common side effects of Trenbolone Enanthate are Oily skin, aggressive behavior, hair loss and high water retention. An aggressive behavior is also reported with a higher dosage of Trenbolone Enanthate. Many athletes have reported that acnes tend to appear on their lower arm, upper arm, shoulder, chest, back, and also in their face during early stages of this drug’s consumption.Women should strictly resist it, under every circumstance.

Doses

The most common dose of Trenbolone Enanthate prescribed is 75 to 100 mg. The dose can be changed according to medical advice. It may be dependent on the physical activity and strata of a person. This need not to be continued for around 10 week as it acts quite rapidly.
Tags: androgenic, cardiovascular, glucocorticoid receptor, gynecomastia, Steroids, testosterone, trenbolone, trenbolone enanthate, veterinary

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Trenbolone (17beta-hydroxyestra-4,9,11-trien-3-one)

Structure

Structurally Trenbolone is a derivative of nandrolone, carrying two additional double carbon bonds at positions 9 and 11 (hence the prefix “Tren,” short for tri-en). The activity of Trenbolone differs from that of its parent hormone considerably, however. To begin with, Trenbolone cannot aromatize to estrogen. The delta-9 group present on its structure occupies a bond necessary for aromatization of the A-Ring to be possible. Unless this group is removed metabolically, which it does not appear to be, estrogen synthesis is impossible in the body. Although nandrolone is a weak substrate for aromatase, estrogen levels can still rise during use. With Trenbolone we actually expect a lowering of serum estrogen levels, as it should suppress endogenous testosterone release (the primary substrate for estradiol in men).

Androgenic Activity

Although derived from nandrolone, Trenbolone is comparatively far more androgenic than this steroid. In fact it is several times stronger in this regard than our primary androgen testosterone as well (1). The first contributing factor to this of course is that Trenbolone is a strong binder of the androgen receptor. This trait is also characteristic of its parent nandrolone, which is several times more active than testosterone in this regard. Androgen binding is in fact further enhanced by the introduction of double bonds in delta-9,11 (2), which makes Trenbolone an even more potent agonist of the androgen receptor than nandrolone. Perhaps more significant though is the fact that unlike nandrolone, the strong receptor binding potency of Trenbolone is not diminished in androgen sensitive tissues by 5-alpha reductase. Trenbolone does not seem to undergo 5-alpha reduction in humans to any appreciable degree at all, which is evidenced by the fact that the major urinary metabolites of Trenbolone all possess the original tri-en structure with an intact delta-4 group (3). So Trenbolone retains its original potency as it enters cells in androgen target tissues with high 5AR concentrations, as this enzyme is not affecting it. These factors work together to allow Trenbolone to be a potently androgenic steroid, instead of a primarily anabolic one in nature like nandrolone.

Progestational Activity

It has been reported in other bodybuilding literature that Trenbolone does not exhibit any activity as a progestin in the body. I am not certain where this belief originated, as Trenbolone does appear to exhibit the classic progesterone receptor binding ability that is characteristic of nandrolone and its derivatives. One study looking at the bovine uterine progesterone receptor for example found Trenbolone to be a very potent binder, startlingly even more so than progesterone itself (4). Another looking at the binding of various compounds to the androgen, estrogen, progestin, mineral corticoid and glucocorticoid receptors found Trenbolone to be a more potent binder of the progestin receptor than nandrolone (5), a steroid normally noted for its usual activity in this regard. What does this mean for Trenbolone? I don’t think it really means that much. Trenbolone clearly doesn’t cause gyno, water retention or fat buildup, which one might attribute to estrogenic or Progestational activity. So whatever slight action it does have as a progestin on paper doesn’t amount to all that much in the real world. The absence of estrogen may be a significant factor, as progesterone is believed to cause gyno by enhancing estrogen’s stimulation of mammary gland growth (6). Perhaps when Trenbolone is taken with other aromatizable compounds it could affect a person’s sensitivity level to gyno and water/fat retention. This seems logical, at least in a technical sense, although admittedly I have seen no evidence to support this.

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Mass or Cutting Agent

The potently androgenic and non-aromatizing nature of Trenbolone makes it an extremely effective hardening and cutting agent. In fact, it is thought of as unmatched in its capacity as a body-sculpting steroid. Many competitive bodybuilders similarly find it indispensable to any good pre-contest cutting stack. For this type of purpose I doubt another steroid would serve you better. Many people do additionally find they make very good muscle gains with Trenbolone. It is a potent muscle-builder, although we should probably not consider it an ideal mass-builder when used alone. The absence of estrogen is an important factor, as this trait seems integral in this type of steroid. This probably has to do not only with water retention but also interactions between estrogen and muscle glucose utilization, GH release and androgen receptor proliferation. Today we are finally starting to understand why this hormone is needed for optimal growth. Trenbolone is probably still the most potent muscle-building agent of all the non-estrogenic steroids though, and admittedly is quite unusual in its potency in this regard. But I would still think that if mass were the goal and you were choosing only one steroid, testosterone, Dianabol or Anadrol would be more productive every time in terms of overall size, weight and muscle mass gain.